Pfizer Super Bowl 2025 TV Spot, 'Knock Out' Song by LL Cool J

A young boy lies in a hospital bed, eyes locked on a boxing match playing on the TV. He looks down at his fists, small but strong; he knows what he must do. Swinging his leg over the bed and dressed in full boxing gear, he rises ready to fight. With confident steps, he walks through the hospital until he reaches the cancer bell. He raises his fist and punches the bell, ringing it three times, symbolizing his victory. "Mama Said Knock You Out" by LL Cool J blasts as he walks through the hospital, head high, with nurses, doctors, and patients cheering him on. The celebration continues outside with a parade full of people rallying him as he makes his way home. He runs down his street, and his mother, overjoyed by her son's return, stands waiting. The boy leaps into her arms for a warm embrace, his father joining them, and the family is together again. During Super Bowl LIX, Pfizer encourages you to join the fight to knock out cancer.